The plasmid is confirmed by full-length sequencing.
Stable or Transient mammalian expression
保存 & 配送
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
CD73 cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
CD73 cDNA ORF Clone, Human, untagged: 検証済の画像
CD73 cDNA ORF Clone, Human, untagged: 別名
CALJA cDNA ORF Clone, Human; CD73 cDNA ORF Clone, Human; E5NT cDNA ORF Clone, Human; eN cDNA ORF Clone, Human; eNT cDNA ORF Clone, Human; NT cDNA ORF Clone, Human; NT5 cDNA ORF Clone, Human; NTE cDNA ORF Clone, Human
5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein which belongs to the5'-nucleotidase family. CD73 is a glycosyl phosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surface of human T and B lymphocytes. CD73 catalyzes the conversion of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to the corresponding nucleosides. CD73 serves as a costimulatory molecule in activating T cells. CD73 generated adenosine functions in cell signalling in many physiologic systems, including intestinal epithelium, ischemic myocardium, and cholinergic synapses. CD73 might mediate lymphocyte-stromal cell interactions or condition the local microenvironment to facilitate lymphocyte development and/or function. In CD73-depleted cells, surface levels of the leukocyte adhesion molecules ICAM-1, VCAM-1 and E-selectin increase. CD73 produces extracellular adenosine, which then acts on G protein-coupled purigenic receptors to induce cellular responses. CD73 has also been reported to regulate expression of pro-inflammatory molecules in mouse endothelium.
5'-nucleotidase, ecto (CD73)
Resta R. et al., 1997, Cell Signal. 9 (2): 131-9.
Yamashita Y. et al., 1998, Eur J Immunol. 28 (10): 2981-90.
Louis NA. et al., 2008, J Immunol. 180 (6): 4246-55.