CD151: CD151 Protein | CD151 Antibody

CD151 Gene family

CD151 Background

Tspan8 and CD151 are metastasis-promoting tetraspanins and a knockdown (kd) of Tspan8 or CD151 and most pronounced of both tetraspanins affects the metastatic potential of the rat pancreatic adenocarcinoma line ASML. CD151- and Tspan8-competent tumor exosomes support matrix degradation, reprogram stroma and hematopoietic cells and drive non-metastatic ASML-CD151/Tspan8kd cells towards a motile phenotype. Distinct contributions of CD151 and Tspan8 to skin wound healing rely on preferentially CD151 anchoring basal keratinocytes and Tspan8 promoting motility. Transfection of non-permissive PK-15 cells with porcine CD151 cDNA conferred the susceptibility to PRRSV infection, indicating an important role of the porcine CD151 in PRRSV infection of porcine cells.

Reference for CD151

  • Huang Y, et al. (2013) [establishment of a porcine cd151 transgenic pk-15 cell line susceptible to porcine reproductive and respiratory syndrome virus]. Wei Sheng Wu Xue Bao 53(5), 507-514.
  • Yue S, et al. (2015) The tetraspanins cd151 and tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding. Oncotarget 6(4), 2366-2384.
  • Zhao K, et al. (2018) Distorted leukocyte migration, angiogenesis, wound repair and metastasis in tspan8 and tspan8/cd151 double knockout mice indicate complementary activities of tspan8 and cd51. Biochim Biophys Acta 1865(2), 379-391.

CD151 Protein

CD151 protein function

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. {ECO:0000269|PubMed:15265795}.; (Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor. {ECO:0000269|PubMed:24553111}.

CD151 protein expression

Tissue specificity

Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.

Induction

By HTLV-1.

CD151 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    253.00
  • Mass (Da)
    28.00

CD151 Antibody

There are 3 CD151 antibodies which are validated in multiple tissues with various applications, including IHC-P, WB. There are 2 CD151 antibody for IHC-P, 1 CD151 antibody for WB. Among all these CD151 antibodies, there are 3 anti-CD151 rabbit polyclonal antibodies . All the CD151 anbodies are produced in house and all are in stock. CD151 antibody customerized service is available.

CD151 Gene

CD151 gene / cDNA is a protein-coding gene which located on 11p15.5. The CD151 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.200 organisms have orthologs with human gene CD151.