CD122 / IL2RB cDNA ORF Clone in Cloning Vector, Human

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CD122 / IL2RB cDNA ORF Clone in Cloning Vector, Human: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
1656 bp
シーケンスの特徴
Identical with the Gene Bank Ref. ID sequence except for the 1173 C/A point mutation which results in the 391Asp substitution by Glu.
製品の特徴
Full length Clone DNA of Human interleukin 2 receptor, beta.
プラスミド
ベクター
シークエンシングプライマー
M13-47 and RV-M
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Ampicillin
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

CD122 / IL2RB cDNA ORF ヌクレオチド配列およびアミノ酸配列に関する情報

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CD122 / IL2RB cDNA ORF Clone in Cloning Vector, Human: 別名

CD122 cDNA ORF Clone, Human; IL-15RB cDNA ORF Clone, Human; IL15RB cDNA ORF Clone, Human; P70-75 cDNA ORF Clone, Human

CD122 / IL2RB 背景情報

Interleukin-2 receptor (IL-2R) also known as High affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B22+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development.
完全な名称
interleukin 2 receptor, beta
参考文献
  • Foss F. (2006) Clinical experience with denileukin diftitox (ONTAK). Semin Oncol. 33(1 Suppl 3): 11-6.
  • Sprent J, et al. (2001) T cell death and memory. Science. 293(5528): 245-8.
  • Teshigawara K, et al. (1987) Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med. 165 (1): 223-38.
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