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Anti-FABP4 Antibody

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Anti-FABP4 Antibody (Rabbit Monoclonal 抗体) の製品情報

製品名
Anti-FABP4 Antibody
検証済のアプリケーション
IHC-P,FCM
交差反応
Reacts with: Human
特異性
Human FABP4
Has cross-reactivity in ELISA with
Mouse FABP3
No cross-reactivity in ELISA with
Human FABP6
免疫原
Recombinant Human FABP4 / ALBP / A-FABP protein (Catalog#12109-H07E)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human FABP4 / ALBP / A-FABP (rh FABP4 / ALBP / A-FABP; Catalog#12109-H07E; P15090; Cys2-Ala132,29Ala/Thr).
ソース
Monoclonal Rabbit IgG Clone #001
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-FABP4 Antibody (Rabbit Monoclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
IHC-P 1:1000-1:4000
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-FABP4 Antibody (Rabbit Monoclonal 抗体) の画像

Immunochemical staining of human FABP4 in human lung cancer with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human FABP4 in human appendix with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Flow cytometric analysis of Human FABP4 expression on Hela cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human FABP4, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-FABP4 Antibody: 別名

Anti-A-FABP Antibody; Anti-AFABP Antibody; Anti-ALBP Antibody; Anti-aP2 Antibody; Anti-HEL-S-104 Antibody

FABP4 背景情報

Fatty acid-binding protein, adipocyte, also known as Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, and FABP4, is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. In familial combined hyperlipidemia (FCHL), FABP4 correlated to body mass index (BMI), waist circumference and homeostasis model assessment (HOMA) index.FABP4 levels were associated with triglyceride-rich lipoproteins. In humans serum FABP4 levels correlate significantly with features of PCOS. It appears to be a determinant of atherogenic dyslipidemia. FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. FABP4 concentration significantly increased with an increasing of MS features and was strongly correlated with body-mass index, triglycerides, HDL-cholesterol concentrations and blood pressure. Patients in the highest quartile of FABP4 presented a six-fold increased odds ratio for MS and a three-fold increased odds for LD, adjusted by age, sex, body-mass index and the antiretroviral therapy. FABP4 is a strong plasma marker of metabolic disturbances in HIV-infected patients, and therefore, could serve to guide therapeutic intervention in this group of patients.
完全な名称
fatty acid binding protein 4, adipocyte
参考文献
  • van Dongen,M.J. et al., 2002, J Am Chem Soc. 124 (40): 11874-80.
  • Coll, B. et al., 2008, Atherosclerosis  199 (1):147-53.
  • Hoashi,S. et al., 2008, BMC Genet. 9 :84.
  • Cai,H. et al., 2010, Bioorg Med Chem Lett  20 (12):3675-9.

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