Anti-IL4R Antibody (APC)

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Anti-IL4R Antibody (APC) (Rabbit Monoclonal 抗体) の製品情報

製品名
Anti-IL4R Antibody (APC)
検証済のアプリケーション
FCM
交差反応
Reacts with: Rat
特異性
Rat IL4R
免疫原
Recombinant Rat IL4R Protein (Catalog#80198-R08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Rat IL4R (rR IL4R; Catalog#80198-R08H; Q63257-1; Met1-Arg232) and conjugated with APC under optimum conditions, the unreacted APC was removed.
ソース
Monoclonal Rabbit IgG Clone #002
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
標識物
APC
濃度
5 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !

Anti-IL4R Antibody (APC) (Rabbit Monoclonal 抗体) の画像

Flow cytometric analysis of rat IL4R expression on SD rat splenocytes. Cells were stained with APC-conjugated anti-rat IL4R. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-IL4R Antibody (APC): 別名

Anti-IL4R Antibody; Anti-Il4ra Antibody

IL4R 背景情報

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD124, also known as interleukin 4 receptor (IL4R), is a typeⅠ transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.
完全な名称
interleukin 4 receptor
参考文献
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.

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