Vitronectin (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All Vitronectin reagents are produced in house and quality controlled, including 9 Vitronectin Antibody, 2 Vitronectin ELISA, 39 Vitronectin Gene, 2 Vitronectin Lysate, 2 Vitronectin Protein, 3 Vitronectin qPCR. All Vitronectin reagents are ready to use.

Vitronectin Protein (2)

Vitronectin Antibody (9)

Vitronectin ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

Vitronectin cDNA Clone (39)

NM_000638.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_011707.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_019156.2

クローニングベクター cDNA 製品

In lentiviral vector

Vitronectin Lysate (2)

Vitronectin の背景知識

Vitronectin, also known as VTN, is a member of the pexin family. It is an abundant glycoprotein found in serum the extracellular matrix and promotes cell adhesion and spreading. Vitronectin is a secreted protein and exists in either a single chain form or a cleaved, two chain form held together by a disulfide bond. Vitronectin is a plasma glycoprotein implicated as a regulator of diverse physiological process, including blood coagulation, fibrinolysis, pericellular proteolysis, complement dependent immune responses, and cell attachment and spreading. Because of its ability to bind platelet glycoproteins and mediate platelet adhesion and aggregation at sites of vascular injury, vitronectin has become an important mediator in the pathogenesis of coronary atherosclerosis. As a multifunctional protein with a multiple binding domain, Vitronectin interacts with a variety of plasma and cell proteins. Vitronectin binds multiple ligands, including the soluble vitronectin receptor. It may be an independent predictor of adverse cardiovascular outcomes following acute stenting. Accordingly, Vitronectin is suggested to be involved in hemostasis, cell migration, as well as tumor malignancy.

Vitronectin の参考文献

  • Ekmeki OB, et al. (2006) Vitronectin in atherosclerotic disease. Clin Chim Acta. 368(1-2): 77-83.
  • Derer W, et al. (2009) Vitronectin concentrations predict risk in patients undergoing coronary stenting. Circ Cardiovasc Interv. 2(1): 14-9.
  • Heyman L, et al. (2010) Mesothelial vitronectin stimulates migration of ovarian cancer cells. Cell Biol Int. 34(5): 493-502.