All VSIG4 reagents are produced in house and quality controlled, including 9 VSIG4 Antibody, 2 VSIG4 ELISA, 27 VSIG4 Gene, 4 VSIG4 Lysate, 4 VSIG4 Protein, 2 VSIG4 qPCR. All VSIG4 reagents are ready to use.
Recombinant VSIG4 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His, C-human IgG1-Fc & His.
VSIG4antibodies are validated with different applications, which are ELISA, ELISA(Cap), ELISA(Det), IHC-P.
VSIG4cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each VSIG4 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
VSIG4ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
VSIG4 (V-set and immunoglobulin domain containing 4), also known as complement receptor of the immunoglobulin superfamily (CRIg) and Z39Ig, is a type I transmembrane glycoprotein. It is a B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type I g domain and a truncated C-type I g domain. VSIG4 is exclusively expressed on tissue resident macrophages and binds to multimers of C3b and iC3b that are covalently attached to particle surfaces. No VSIG4 expression appears to be present in T and B cells. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. Mouse VSIG4 is synthesized as a 280 amino acid precursor that contains a signal sequence, an V-type I g domain (aa 36-115), one potential N-linked glycosylation site, and a single transmembrane domain. The V-type I g domain of mouse VSIG4 shares 86% and 80% aa sequence identity with the V-type I g domains of rat and human VSIG4, respectively.