FLT4 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All FLT4 reagents are produced in house and quality controlled, including 10 FLT4 Antibody, 2 FLT4 ELISA, 29 FLT4 Gene, 4 FLT4 Lysate, 4 FLT4 Protein, 2 FLT4 qPCR. All FLT4 reagents are ready to use.

FLT4 Protein (4)

FLT4 Antibody (10)

FLT4 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

FLT4 cDNA Clone (29)

NM_002020.4

クローニングベクター cDNA 製品

In lentiviral vector

NM_182925.4

In expression vector

In lentiviral vector

NM_008029.2

クローニングベクター cDNA 製品

In lentiviral vector

FLT4 Lysate (4)

FLT4 の背景知識

Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.

FLT4 の参考文献

  • Shushanov S, et al. (2000)VEGFc and VEGFR3 expression in human thyroid pathologies. Int J Cancer.86(1): 47-52.
  • Iljin K, et al. (2001) VEGFR3 gene structure, regulatory region, and sequence polymorphisms. FASEB J. 15(6): 1028-36.
  • Liu XE, et al. (2004) Expression and significance of VEGF-C and FLT-4 in gastric cancer. World J Gastroenterol. 10(3): 352-5.
  • Stearns ME, et al. (2004) Expression of a flt-4 (VEGFR3) splicing variant in primary human prostate tumors. VEGF D and flt-4t(Delta773-1081) overexpression is diagnostic for sentinel lymph node metastasis. Lab Invest. 84(6): 785-95.