クイック注文

VEGF/VEGFA/VEGF165  Protein, Antibody, ELISA Kit, cDNA Clone

製品の説明: Active  
発現宿主: Baculovirus-Insect Cells  
  • Slide 1
11066-HNAB-20
11066-HNAB-100
11066-HNAB-500
11066-HNAB-5
11066-HNAB-1
20 µg 
100 µg 
500 µg 
5 µg 
1 mg 
Add to Cart
製品の説明: Active  
発現宿主: Baculovirus-Insect Cells  
  • Slide 1
10008-HNAB-5
10008-HNAB-500
10008-HNAB-100
10008-HNAB-1
10008-HNAB-20
5 µg 
500 µg 
100 µg 
1 mg 
20 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
10008-HNAH-10
10008-HNAH-20
10 µg 
20 µg 
Add to Cart
製品の説明: Active  
発現宿主: Human Cells  
  • Slide 1
11066-HNAH-5
11066-HNAH-20
11066-HNAH-500
11066-HNAH-100
11066-HNAH-1
5 µg 
20 µg 
500 µg 
100 µg 
1 mg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
15692-HNAH-20
15692-HNAH-50
20 µg 
50 µg 
Add to Cart
製品の説明: Active  
発現宿主: Baculovirus-Insect Cells  
  • Slide 1
50159-MNAB-20
50159-MNAB-500
50159-MNAB-100
50159-MNAB-1
50159-MNAB-5
20 µg 
500 µg 
100 µg 
1 mg 
5 µg 
Add to Cart
製品の説明: Active  
発現宿主: Baculovirus-Insect Cells  
  • Slide 1
80006-RNAB-20
80006-RNAB-5
80006-RNAB-100
20 µg 
5 µg 
100 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
70004-DNAH-10
70004-DNAH-20
10 µg 
20 µg 
Add to Cart
製品の説明: Active  
発現宿主: Baculovirus-Insect Cells  
  • Slide 1
63004-ZNAB-5
63004-ZNAB-100
63004-ZNAB-20
5 µg 
100 µg 
20 µg 
Add to Cart

VEGF/VEGFA/VEGF165 関連経路

VEGF/VEGFA/VEGF165 関連製品

VEGF/VEGFA/VEGF165 サマリー & タンパク質情報

VEGF/VEGFA/VEGF165 背景

サブユニット構造: Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity).
細胞内位置: Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
組織特異性: Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed.
誘導: Regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia, hypoglycemia and oncogenic mutations.
疾患関連性: Microvascular complications of diabetes 1 (MVCD1) [MIM:603933]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end- stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
シーケンスの類似性: Belongs to the PDGF/VEGF growth factor family.
General information above from UniProt

Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, inhibiting apoptosis and tumor growth. VEGF-A protein is also a vasodilator that increases microvascular permeability, thus it was originally referred to as vascular permeability factor.

VEGF/VEGFA/VEGF165 代替名

VEGF/VEGFA/VEGF165 関連研究

  • Woolard J. et al. (2004) VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res. 64(21): 7822-7835.
  • Jia SF, et al. (2008) VEGF165 is necessary to the metastatic potential of Fas(-) osteosarcoma cells but will not rescue the Fas(+) cells. J Exp Ther Oncol. 7(2): 89-97.
  • Cimpean AM, et al. (2008) Vascular endothelial growth factor A (VEGF A) as individual prognostic factor in invasive breast carcinoma. Rom J Morphol Embryol. 49(3): 303-8.
  • Hamdollah Zadeh MA, et al. (2008) VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. Microcirculation. 15(7): 605-14.
  • Eisenach PA, et al. (2010) MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src. J Cell Sci. 123(Pt 23):4182-4193.
  • Claesson-Welsh L (2010) Gremlin: vexing VEGF receptor agonist. Blood. 116(18):3386-7.
  • 注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"