UBE2F (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All UBE2F reagents are produced in house and quality controlled, including 1 UBE2F Antibody, 32 UBE2F Gene, 1 UBE2F Protein. All UBE2F reagents are ready to use.

UBE2F Protein (1)

UBE2F Antibody (1)

UBE2F cDNA Clone (32)

NM_080678.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_026454.3

クローニングベクター cDNA 製品

In lentiviral vector

XM_006245422.2

クローニングベクター cDNA 製品

In lentiviral vector

UBE2F の背景知識

UBE2F is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To deal with this complexity and to allow adequate ubiquitination in time and space, a highly sophisticated conjugation machinery has been developed. In a sequential manner, ubiquitin becomes activated by an ubiquitin-activating enzyme (E1), which then transfers the ubiquitin to a group of ubiquitin-conjugating enzymes (E2s). Next, ubiquitin-loaded E2s are interacting with ubiquitin protein ligases (E3s) and ubiquitin is conjugated to substrates on recruitment by the E3. These three key enzymes are operating in a hierarchical system, wherein two E1s and 35 E2s have been found and hundreds of E3s have been identified in humans.

UBE2F の参考文献

  • Sjoerd J L van Wijk, et al. (2009) A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Mol Syst Biol. 5: 317.
  • Nandi D, et al. (2006) The ubiquitin-proteasome system. Journal of biosciences. 31 (1): 137-55.