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TRAIL R4 / CD264 / TNFRSF10D 抗体, ウサギモノクローナル抗体

    データシートレビュー関連製品プロトコル
    人々 TNFRSF10D 抗体製品情報
    免疫原:Recombinant Human TRAIL R4 / CD264 / TNFRSF10D protein (Catalog#10413-H08H)
    Clone ID:043
    Ig タイプ:Rabbit IgG
    濃度:
    エンドトキシン:
    製剤:0.2 μm filtered solution in PBS with 5% trehalose
    調製:This antibody was obtained from a rabbit immunized with purified, recombinant Human TRAIL R4 / CD264 / TNFRSF10D (rh TRAIL R4 / CD264 / TNFRSF10D; Catalog#10413-H08H; NP_003831.2; Met1-His211).
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    反応度: Human  
    アプリケーション: 
      10413-MM09-50
      10413-MM09-200
      10413-MM09-100
      10413-MM09-1
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      反応度: Human  
      アプリケーション: ELISA  
        10413-RP02-50
        10413-RP02-200
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        アプリケーション: ELISA  IHC-P  
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        10413-MM04-50
        10413-MM04-200
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        反応度: Human  
        アプリケーション: ELISA  
          10413-RP01-400
          10413-RP01-200
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          反応度: Human  
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            10413-R137-50
            10413-R137-100
            50 µg 
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            反応度: Human  
            アプリケーション: 
              10413-MM08-50
              10413-MM08-200
              10413-MM08-100
              10413-MM08-1
              50 µg 
              200 µg 
              100 µg 
              1 mg 
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              反応度: Human  
              アプリケーション: IHC-P  
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              10413-R009-50
              10413-R009-100
              50 µg 
              100 µg 
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              反応度: Human  
              アプリケーション: ELISA  WB  IHC-P  IP  
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              10413-T60-50
              10413-T60-200
              10413-T60-100
              50 µg 
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              反応度: Rhesus  
              アプリケーション: ELISA  
                90100-RP01-400
                90100-RP01-200
                90100-RP01-100
                400 µg 
                200 µg 
                100 µg 
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                反応度: Rhesus  
                アプリケーション: ELISA  IHC-P  
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                90100-T24-50
                90100-T24-200
                90100-T24-100
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                TRAIL R4/CD264/TNFRSF10D 背景

                Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), also known as TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4), CD264, and Decoy receptor 2, is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. TRAIL R4/CD264/TNFRSF10D is widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. TRAIL R4/CD264/TNFRSF10D is also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. The signaling capacity of TRAIL R4 is similar to that of TRAIL R1 and TRAIL R2 with respect to NF-κB activation, but differs in its inability to induce apoptosis. TRAIL R4 retains a C-terminal element containing one third of a consensus death domain motif. Transient overexpression of TRAIL R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAIL R4 may be inhibition of TRAIL cytotoxicity.

                人々 TRAIL R4/CD264/TNFRSF10D 参考文献
              • Degli-Esposti MA, et al. (1997) The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity. 7(6): 813-20.
              • Meng RD, et al. (2000) The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis. Mol Ther. 1(2): 130-44.
              • Bouralexis S, et al. (2003) Progressive resistance of BTK-143 osteosarcoma cells to Apo2L/TRAIL-induced apoptosis is mediated by acquisition of DcR2/TRAIL-R4 expression: resensitisation with chemotherapy. Br J Cancer. 89(1): 206-14.
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                Size / Price
                カタログ: 10413-R043-50
                定価: 
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                Datasheet & Documentation

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