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TNFSF18  Protein, Antibody, ELISA Kit, cDNA Clone

TNFSF18 Related Area

TNFSF18 関連経路

    TNFSF18 サマリー & タンパク質情報

    TNFSF18 背景

    サブユニット構造: Homodimer (By similarity). Homotrimer. {ECO:0000250, ECO:0000269|PubMed:18040044}.
    細胞内位置: Cell membrane {ECO:0000269|PubMed:17449724}; Single-pass type II membrane protein {ECO:0000269|PubMed:17449724}.
    組織特異性: Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
    誘導: Up-regulated after stimulation by bacterial lipopolysaccharides (LPS).
    シーケンスの類似性: Belongs to the tumor necrosis factor family. {ECO:0000305}.
    General information above from UniProt

    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.

    Immune Checkpoint
    Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    TNFSF18 代替名

    TL6,AITRL,GITRL,hGITRL, [homo-sapiens]
    Gitrl, [mus-musculus]

    TNFSF18 関連研究

  • Liu Y, Tang X, Tian J, et al. Th17/Treg Cells Imbalance and GITRL Profile in Patients with Hashimoto’s Thyroiditis. Nicot C, ed. International Journal of Molecular Sciences. 2014;15(12):21674-21686.
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