All TLR4 reagents are produced in house and quality controlled, including 1 TLR4 Antibody, 52 TLR4 Gene, 1 TLR4 Lysate, 1 TLR4 Protein, 3 TLR4 qPCR. All TLR4 reagents are ready to use.
Recombinant TLR4 proteins are expressed by Baculovirus-Insect Cells with fusion tags as C-His.
TLR4antibodies are validated with different applications, which are ELISA.
TLR4cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each TLR4 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. TLR 4 has also been designated as CD284 (cluster of differentiation 284). It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). It acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. It is also involved in LPS-independent inflammatory responses triggered by Ni(2+).