TIM-3 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All TIM-3 reagents are produced in house and quality controlled, including 10 TIM-3 Antibody, 2 TIM-3 ELISA, 16 TIM-3 Gene, 1 TIM-3 IP Kit, 7 TIM-3 Lysate, 7 TIM-3 Protein, 1 TIM-3 qPCR. All TIM-3 reagents are ready to use.

TIM-3 Protein (7)

TIM-3 Antibody (10)

TIM-3 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

TIM-3 cDNA Clone (16)

NM_032782.3

クローニングベクター cDNA 製品

In lentiviral vector

BC106852.2

In expression vector

XM_006246171.3

In expression vector

In lentiviral vector

TIM-3 qPCR Primer (1)

TIM-3 Lysate (7)

TIM-3 関連の研究分野

TIM-3 の背景知識

Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In tumor rejection model, soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.

TIM-3 の参考文献

  • Geng H, et al. (2006) Soluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune response. J Immunol. 176(3): 1411-20.
  • Anderson AC, et al. (2006) TIM-3 in autoimmunity. Curr Opin Immunol. 18(6): 665-9.
  • Anderson DE. (2007) TIM-3 as a therapeutic target in human inflammatory diseases. Expert Opin Ther Targets. 11(8): 1005-9.
  • Pan HF, et al. (2010) TIM-3 as a new therapeutic target in systemic lupus erythematosus. Mol Biol Rep. 37(1): 395-8.