TIGIT (Protein|Antibody|cDNA Clone|ELISA Kit)

All TIGIT reagents are produced in house and quality controlled, including 4 TIGIT Antibody, 31 TIGIT Gene, 6 TIGIT Lysate, 6 TIGIT Protein, 2 TIGIT qPCR. All TIGIT reagents are ready to use.

Recombinant TIGIT proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.

TIGIT antibodies are validated with different applications, which are ELISA, IHC-P.

TIGIT cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each TIGIT of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

TIGIT Protein (6)

Species

TIGIT Protein, Human, Recombinant (Fc Tag), Biotinylated

10917-H02H-B

Expression host: HEK293 Cells

Human TIGIT/VSTM3 Protein 18581

TIGIT Protein, Human, Recombinant (His Tag), Biotinylated

10917-H08H-B

Expression host: HEK293 Cells

Human TIGIT/VSTM3 Protein 18582

TIGIT Protein, Mouse, Recombinant (Fc Tag)

50939-M02H

Expression host: HEK293 Cells

Mouse TIGIT/VSTM3 Protein 11979

TIGIT Protein, Mouse, Recombinant (His Tag)

50939-M08H

Expression host: HEK293 Cells

Mouse TIGIT/VSTM3 Protein 11980

TIGIT Protein, Human, Recombinant (Fc Tag)

10917-H02H

Expression host: HEK293 Cells

Human TIGIT/VSTM3 Protein 17076

TIGIT Protein, Human, Recombinant (His Tag)

10917-H08H

Expression host: HEK293 Cells

Human TIGIT/VSTM3 Protein 9226
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TIGIT Antibody (4)

Application Clonality
Host

Anti-TIGIT Antibody

10917-T16

Specificity: Human

Application: ELISA

Clonality: PAb

Anti-TIGIT Antibody

50939-RP01

Specificity: Mouse

Application: ELISA

Clonality: PAb

Anti-TIGIT Antibody

50939-T16

Application: ELISA

Clonality: PAb

Anti-TIGIT Antibody

50939-T24

Specificity: Mouse

Application: ELISA,IHC-P

Clonality: PAb

Mouse TIGIT/VSTM3 Immunohistochemistry(IHC) 3167
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TIGIT cDNA Clone (31)

Human
Mouse
Rat
Rhesus
Cynomolgus
XM_008768765.1
XM_015129816.1
XM_005548101.2

TIGIT qPCR Primer (2)

TIGIT Lysate (6)

TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-1 and diminished the production of IL-12p4. In addition, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition.Immune Checkpoint
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy
Protein
Antibody
Gene
qPCR
Lysate
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