All TGF beta 1 reagents are produced in house and quality controlled, including 12 TGF beta 1 Antibody, 2 TGF beta 1 ELISA, 52 TGF beta 1 Gene, 2 TGF beta 1 IPKit, 8 TGF beta 1 Lysate, 8 TGF beta 1 Protein, 3 TGF beta 1 qPCR. All TGF beta 1 reagents are ready to use.
Recombinant TGF beta 1 proteins are expressed by HEK293 Cells, CHO Stable Cells with fusion tags as C-His, Native.
TGF beta 1antibodies are validated with different applications, which are WB, ELISA, ELISA(Cap), IP.
TGF beta 1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each TGF beta 1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
TGF beta 1ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.