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SIRPA/SIRP alpha/CD172a  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
  • Slide 1
11612-H08H-50
11612-H08H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
50956-M08H-50
50956-M08H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
50956-M02H-50
50956-M02H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
  • Slide 1
80270-R08H-50
80270-R08H-100
50 µg 
100 µg 
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SIRPA/SIRP alpha/CD172a 関連経路

    SIRPA/SIRP alpha/CD172a サマリー & タンパク質情報

    SIRPA/SIRP alpha/CD172a 背景

    遺伝子の概要: The protein encoded by SIRPA gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. SIRPA gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for SIRPA gene. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    サブユニット構造: Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.
    細胞内位置: Membrane; Single-pass type I membrane protein.
    組織特異性: Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
    翻訳後: N-glycosylated.
    Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.
    シーケンスの類似性: Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.C
    General information above from UniProt

    Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antigen-like family member A, SIRPA and CD172a, is a single-pass type I membrane protein which contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIRPA is ubiquitously expressed. It is highly expressed in brain and detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. It is also detected on myeloid cells, but not T-cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPA acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. It may play a key role in intracellular signaling during synaptogenesis and in synaptic function. SIRPA is involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. It mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.

    SIRPA/SIRP alpha/CD172a 代替名

    BIT,MFR,P84,SIRP,MYD-1,SHPS1,CD172A,PTPNS1, [homo-sapiens]
    BIT,CD172A,MFR,MYD-1,P84,PTPNS1,SHPS1,SIRP,SIRP alpha, [human]
    AI835480,Bit,CD172a,P84,Ptpns1,RP23-37B4.2,SHP-1,SHPS-1,SIRP,SIRP alpha, [mouse]
    p84,SHP-1,Bit,SIRP,CD172a,Ptpns1,SHPS-1,AI835480, [mus-musculus]

    SIRPA/SIRP alpha/CD172a 関連研究

  • Timms JF. et al., 1999, Curr Biol. 9: 927-30.
  • Stofega MR. et al., 2000, J Biol Chem. 275: 28222-9.
  • Liu T. et al., 2005, J Proteome Res. 4: 2070-80.
  • Wolf-Yadlin A. et al., 2007, Proc Natl Acad Sci. 104: 5860-5.
  • 注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"