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SCGN / Secretagogin 抗体, マウスモノクローナル抗体

  • SCGN / Secretagogin Antibody, Mouse MAb, Immunohistochemistry
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人々 SCGN 抗体製品情報
免疫原:Recombinant Human SCGN / Secretagogin protein (Catalog#12411-H07E)
Clone ID:06
Ig タイプ:Mouse IgG1
濃度:
エンドトキシン:
製剤:0.2 μm filtered solution in PBS with 5% trehalose
調製:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SCGN / Secretagogin (rh SCGN / Secretagogin; Catalog#12411-H07E; NP_008929.2; Asp2-Pro276). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
人々 SCGN Antibody IHC Application Image
SCGN / Secretagogin Antibody, Mouse MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human SCGN in human pancreas with mouse monoclonal antibody (15 µg/mL, formalin-fixed paraffin embedded sections).
Other SCGN Antibody Products
SCGN / Secretagogin 背景

Secretagogin, also known as SCGN, is a secreted protein which is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin / SCGN is restricted to distinct subtypes of neurons with highest expression in the molecular layer of the cerebellum (stellate and basket cells), in the anterior part of the pituitary gland, in the thalamus, in the hypothalamus and in a subgroup of neocortical neurons. Secretagogin / SCGN is widely expressed in prostatic adenocarcinoma as opposed to adenocarcinomas in other organs. The function of Secretagogin / SCGN is unknown, but it has been suggested in beta-cells to influence calcium-influx and has been observed downregulated in diabetes-prone BB rat islets exposed to cytokines. Secretagogin / SCGN is involved in the calcium metabolism of tumour cells and endothelial cells in a subset of neoplasms of the brain and its coverings. Secretagogin / SCGN is also a novel marker for neuroendocrine differentiation.

人々 SCGN / Secretagogin 参考文献
  • Birkenkamp-D,K. et al., 2005, Neuroendocrinology. 82 (2):121-38.
  • Skovhus,K.V. et al., 2006, Scand J Immunol. 64 (6):639-45.
  • Pipp,I. et al., 2007, APMIS.115 (4):319-26.
  • Rogstam, A. et al., 2007, Biochem J. 401 (1):353-63.
  • Adolf,K. et al., 2007, Prostate. 67 (5):472-84.
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    カタログ: 12411-MM06-50
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