S100A16 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All S100A16 reagents are produced in house and quality controlled, including 2 S100A16 Antibody, 45 S100A16 Gene, 1 S100A16 IP Kit, 1 S100A16 Protein, 3 S100A16 qPCR. All S100A16 reagents are ready to use.

S100A16 の背景知識

S1A16 is a member of S1 protein super family that carries calcium-binding EF-hand motifs. S1 proteins are cell- and tissue-specific and are involved in many intra- and extracellular processes through interacting with specific target proteins. S1A16 expression was found to be astrocyte-specific. The S1A16 protein was found to accumulate within nucleoli and to translocate to the cytoplasm in response to Ca(2+) stimulation. The homodimeric structure of human S1A16 in the apo state has been obtained both in the solid state and in solution, resulting in good agreement between the structures with the exception of two loop regions. The homodimeric solution structure of human S1A16 was also calculated in the calcium(II)-bound form. Differently from most S1 proteins, the conformational rearrangement upon calcium binding is minor. Immunoprecipitation analysis revealed that S1A16 could physically interact with tumor suppressor protein p53, also a known inhibitor of adipogenesis. Overexpression or RNA interference-initiated reduction of S1A16 led to the inhibition or activation of the expression of p53-responsive genes, respectively. S1A16 protein is a novel adipogenesis-promoting factor.

S100A16 の参考文献

  • Sturchler E, et al. (2006) S100A16, a novel calcium-binding protein of the EF-hand superfamily. J Biol Chem. 281(50): 38905-17.
  • Liu Y, et al. (2011) Identification of S100A16 as a Novel Adipogenesis Promoting Factor in 3T3-L1 Cells. Endocrinology. 152(3): 903-11.
  • Babini E, et al. (2011) Structural characterization of human S100A16, a low-affinity calcium binder. J Biol Inorg Chem. 16(2): 243-56.