S100A15 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All S100A15 reagents are produced in house and quality controlled, including 1 S100A15 Antibody, 16 S100A15 Gene, 1 S100A15 Protein, 1 S100A15 qPCR. All S100A15 reagents are ready to use.

S100A15 関連の研究分野

S100A15 の背景知識

Koebnerisin is also known as protein S1-A7A (S1A7A), S1 calcium-binding protein A7-like 1 (S1A7L1) or S1 calcium-binding protein A15 (S1A15). Human S1A7A / S1A15 is a novel member of the S1 family of EF-hand calcium-binding proteins and was recently identified in psoriasis, where it is significantly upregulated in lesional skin. S1A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S1A7 plays a role in the pathogenesis of inflammatory skin disease, as a chemotactic factor for hematopoietic cells. It also plays a role in early stages of breast tumor progression in association with the development of the invasive phenotype. The association of the 11.2 kDa S1A7A / S1A15 with psoriasis suggests that it contributes to the pathogenesis of the disease and could provide a molecular target for therapy.

S100A15 の参考文献

  • Wolf R, et al. (2009) Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer. Cancer Lett. 277 (1): 101-7.
  • Buchau AS, et al. (2007) S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4. J Invest Dermatol. 127 (11): 2596-604.
  • Boeshans KM, et al. (2006) Purification, crystallization and preliminary X-ray diffraction of human S100A15. Acta Crystallogr Sect F Struct Biol Cryst Commun. 62 (5): 467-70.