|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat CDH17 ORF mammalian expression plasmid, C-GFPSpark tag||RG80283-ACG|
|Rat CDH17 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80283-ACR|
|Rat CDH17 ORF mammalian expression plasmid, C-Flag tag||RG80283-CF|
|Rat CDH17 ORF mammalian expression plasmid, C-His tag||RG80283-CH|
|Rat CDH17 ORF mammalian expression plasmid, C-Myc tag||RG80283-CM|
|Rat CDH17 ORF mammalian expression plasmid, C-HA tag||RG80283-CY|
|Rat CDH17 Gene cDNA clone plasmid||RG80283-G|
|Rat CDH17 ORF mammalian expression plasmid, N-Flag tag||RG80283-NF|
|Rat CDH17 ORF mammalian expression plasmid, N-His tag||RG80283-NH|
|Rat CDH17 ORF mammalian expression plasmid, N-Myc tag||RG80283-NM|
|Rat CDH17 ORF mammalian expression plasmid, N-HA tag||RG80283-NY|
|Rat CDH17 natural ORF mammalian expression plasmid||RG80283-UT|
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.