RUVBL1: RUVBL1 Protein | RUVBL1 Antibody

RUVBL1 Gene family

RUVBL1 Background

RUVBL1, also known as RVB1, is a component of the NuA4 histone acetyltransferase complex and belongs to the RuvB family. RUVBL1 is ubiquitously expressed with high expression in heart, skeletal muscle and testis. It possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. RUVBL1 is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. It also is essential for cell proliferation. RUVBL1 may be able to bind plasminogen at cell surface and enhance plasminogen activation.

Reference for RUVBL1

  • Bauer A, et al. (1998) Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein. Proc Natl Acad Sci. 95(25):14787-92.
  • Ewing, et al. (2007) Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 3(1):89.
  • Puri T, et al. (2007) Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex. J Mol Biol. 366(1):179-92.

RUVBL1 Protein

RUVBL1 protein function

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.; Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation.; May be able to bind plasminogen at cell surface and enhance plasminogen activation.

RUVBL1 protein expression

Tissue specificity

Ubiquitously expressed with high expression in heart, skeletal muscle and testis.

RUVBL1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    456.00
  • Mass (Da)
    50.00

RUVBL1 Antibody

There are 3 RUVBL1 antibodies which are validated in multiple tissues with various applications, including IHC-P, WB, ELISA, IP. There are 3 RUVBL1 antibody for IHC-P, 1 RUVBL1 antibody for WB, 1 RUVBL1 antibody for ELISA, 1 RUVBL1 antibody for IP. Among all these RUVBL1 antibodies, there are 2 anti-RUVBL1 rabbit polyclonal antibodies , 1 anti-RUVBL1 mouse monoclonal antibodies . All the RUVBL1 anbodies are produced in house and all are in stock. RUVBL1 antibody customerized service is available.

RUVBL1 Gene

RUVBL1 gene / cDNA is a protein-coding gene which located on 3q21.3. The RUVBL1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.235 organisms have orthologs with human gene RUVBL1.