クイック注文

R-Spondin 1/RSPO1  Protein, Antibody, ELISA Kit, cDNA Clone

製品の説明: Active  
発現宿主: Human Cells  
11083-H08H1-50
11083-H08H1-20
50 µg 
20 µg 
Add to Cart
  • Slide 1
発現宿主: CHO Stable Cells  
11083-HNAS-500
11083-HNAS-5
11083-HNAS-20
11083-HNAS-100
11083-HNAS-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
  • Slide 1
製品の説明: Active  
発現宿主: Human Cells  
11083-H08H-5
11083-H08H-20
11083-H08H-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
製品の説明: Active  
発現宿主: CHO Stable Cells  
50316-M08S-5
50316-M08S-20
50316-M08S-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1

R-Spondin 1/RSPO1 Related Area

R-Spondin 1/RSPO1 関連経路

R-Spondin 1/RSPO1 サマリー & タンパク質情報

R-Spondin 1/RSPO1 背景

遺伝子の概要: RSPO1 gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. [provided by RefSeq, Jul 2008]
General information above from NCBI
サブユニット構造: Interacts with the extracellular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin (By similarity). Interacts with ZNRF3; promoting indirect interaction between ZNRF3 and LGR4 and membrane clearance of ZNRF3. Interacts with LGR4, LGR5 and LGR6. Identified in a complex composed of RNF43, LGR5 and RSPO1. {ECO:0000250, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22575959, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23756651, ECO:0000269|PubMed:23756652, ECO:0000269|PubMed:23809763}.
ドメイン: The FU repeats are required for activation and stabilization of beta-catenin. {ECO:0000250}.
細胞内位置: Secreted {ECO:0000250}.
組織特異性: Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. {ECO:0000269|PubMed:17041600}.
疾患関連性: DISEASE: Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal (PKKSCC) [MIM:610644]: A recessive syndrome characterized by XX (female to male) SRY-independent sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin. Note=The disease is caused by mutations affecting the gene represented in this entry.
シーケンスの類似性: Belongs to the R-spondin family. {ECO:0000305}.; Contains 2 FU (furin-like) repeats. {ECO:0000305}.; Contains 1 TSP type-1 domain. {ECO:0000255|PROSITE-ProRule:PRU00210}.
General information above from UniProt

RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. It also acts as a ligand for frizzled FZD8 and LRP6.

R-Spondin 1/RSPO1 代替名

R-Spondin 1, []
RSPO,CRISTIN3, [homo-sapiens]
CRISTIN3,FLJ40906,RP11-566C13.1,RSPO,RSPO1,R-spondin1, [human]
RP23-325M14.2,Rspo1,Rspondin,R-spondin, [mouse]
Rspondin,R-spondin, [mus-musculus]

R-Spondin 1/RSPO1 関連研究

  • Kamata T, et al. (2004) R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Biochim Biophys Acta. 1676(1):51-62.
  • Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 36(1):40-5.
  • Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.
  • 注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"