PCSK9 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All PCSK9 reagents are produced in house and quality controlled, including 20 PCSK9 Antibody, 5 PCSK9 ELISA, 39 PCSK9 Gene, 14 PCSK9 Lysate, 15 PCSK9 Protein, 3 PCSK9 qPCR. All PCSK9 reagents are ready to use.

PCSK9 Protein (15)

PCSK9 Antibody (20)

PCSK9 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(5)

PCSK9 cDNA Clone (39)

NM_174936.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_153565.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_199253.2

クローニングベクター cDNA 製品

In lentiviral vector

PCSK9 Lysate (14)

PCSK9 の背景知識

Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.

References

PCSK9 の参考文献

  • Sseidah, N.G. et al., 2003, Proc. Natl. Acad. Sci. USA. 100: 928-933.
  • Beyer, T.P. et al., 2007, J. Lipid. Res. 48: 1488-1498
  • Shan, L. et al., 2008, Biochem. Biophys. Res. Commun. 375: 69-73.
  • Benjannet, S. et al., 2005, J. Biol. Chem. 279: 48865-48875.
  • Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.