OX40L (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All OX40L reagents are produced in house and quality controlled, including 1 OX40L Antibody, 52 OX40L Gene, 5 OX40L Lysate, 5 OX40L Protein, 2 OX40L qPCR. All OX40L reagents are ready to use.

OX40L Protein (5)

OX40L Antibody (1)

OX40L cDNA Clone (52)

NM_003326.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_009452.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_053552.1

クローニングベクター cDNA 製品

In lentiviral vector

XM_001101190.2

クローニングベクター cDNA 製品

In lentiviral vector

OX40L Lysate (5)

OX40L の背景知識

OX-4L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-4L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-4L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.

OX40L の参考文献

  • Lei W. et al., 2012, Ann Acad Med Singapore. 41 (5): 200-4.
  • Lee YH. et al., 2012, Hum Immunol. 73 (10): 1050-4.
  • Weiguang Y. et al., 2012, PLoS One. 7 (8): e41277.