All Noggin reagents are produced in house and quality controlled, including 2 Noggin Antibody, 38 Noggin Gene, 1 Noggin IPKit, 4 Noggin Lysate, 4 Noggin Protein, 2 Noggin qPCR. All Noggin reagents are ready to use.
Recombinant Noggin proteins are expressed by HEK293 Cells, HEK293 with fusion tags as C-His, C-hIgG1-Fc, C-cleavage, Native, C-human IgG1-Fc.
Nogginantibodies are validated with different applications, which are WB, IP.
NoggincDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Noggin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities, with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs, Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion.