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NGF / NGFB 抗体, ウサギモノクローナル抗体

  • NGF / NGFB Antibody, Rabbit MAb, Immunohistochemistry
データシートレビュー関連製品プロトコル
人々 NGF 抗体製品情報
免疫原:Recombinant Human NGF / NGFB protein (Catalog#11050-HNAC)
Clone ID:D03
Ig タイプ:Rabbit IgG
濃度:
エンドトキシン:
製剤:0.2 μm filtered solution in PBS
調製:This antibody was obtained from a rabbit immunized with purified, recombinant Human NGF / NGFB (rh NGF / NGFB; Catalog#11050-HNAC; NP_002497.2; Ser122-Arg239).
人々 NGF Antibody IHC Application Image
NGF / NGFB Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human β-NGF in human brain (from 2 donors) with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Other NGF Antibody Products
Immunochemical staining of human CCNF in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
NGF/NGFB/beta-NGF 背景

Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF protein was identified as a large complex consisting of three non-covalently linked subunits, α, β, and γ, among which, the β subunit, called β-NGF (beta-NGF), was demonstrated to exhibits the growth stimulating activity of NGF protein. NGFB/beta-NGF gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. NGF protein acts via at least two receptors on the surface of cells (TrkA and p75 receptors) to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. In addition, previous studies indicated that NGF may also have an important role in the regulation of the immune system.

人々 NGF/NGFB/beta-NGF 参考文献
  • Castellanos MR, et al. (2003) Evaluation of the neurorestorative effects of the murine beta-nerve growth factor infusions in old rat with cognitive deficit. Biochem Biophys Res Commun. 312(4): 867-72.
  • Wang TH, et al. (2008) Effects of pcDNA3-beta-NGF gene-modified BMSC on the rat model of Parkinson's disease. J Mol Neurosci. 35(2): 161-9.
  • Perrard MH, et al. (2009) Redundancy of the effect of TGFbeta1 and beta-NGF on the second meiotic division of rat spermatocytes. Microsc Res Tech. 72(8): 596-602.
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    カタログ: 11050-RD03-50
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    Datasheet & Documentation

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