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マウス Prolyl endopeptidase / PREP Gene ORF cDNA clone expression plasmid

    データシートレビュー関連製品プロトコル
    マウス PREP cDNA クローン製品情報
    Gene_bank_ref_id:NM_011156.2
    cDNA サイズ:2133bp
    cDNA の説明:Full length Clone DNA of Mus musculus prolyl endopeptidase.
    遺伝子の別名:PEP, AI047692
    :Mouse
    ベクター:pCMV3-untagged
    Plasmid:
    制限サイト:
    タグ シーケンス:
    シーケンスの説明:
    Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
    ( We provide with PREP qPCR primers for gene expression analysis, MP200312 )
    Promoter:Enhanced CMV mammalian cell promoter
    Application:Stable or Transient mammalian expression
    Antibiotic in E.coli:Ampicillin
    Antibiotic in mammalian cell:Hygromycin
    Shipping_carrier:Each tube contains lyophilized plasmid.
    保存:The lyophilized plasmid can be stored at room temperature for three months.
    マウス Prolyl endopeptidase / PREP Gene ORF cDNA clone expression plasmid on other vectors
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    マウス Prolyl endopeptidase / PREP Gene ORF cDNA clone expression plasmid, N-Myc タグMG50288-NMJPY51990
    マウス Prolyl endopeptidase / PREP Gene ORF cDNA clone expression plasmid, N-HA タグMG50288-NYJPY51990
    マウス Prolyl endopeptidase / PREP Gene ORF cDNA clone expression plasmidMG50288-UTJPY51990
     発現ベクターの詳細情報
    Product nameProduct name
    背景

    Prolyl endopeptidase, also known as PREP, belongs to a distinct class of serine peptidases. It is a large cytosolic enzyme which was first described in the cytosol of rabbit brain as an oligopeptidase. Prolyl endopeptidase degrades the nonapeptide bradykinin at the Pro-Phe bond. It is involved in the maturation and degradation of peptide hormones and neuropeptides such as alpha-melanocyte-stimulating hormone, luteinizing hormone-releasing hormone (LH-RH), thyrotropin-releasing hormone, angiotensin, neurotensin, oxytocin, substance P and vasopressin. Prolyl endopeptidase's activity is confined to action on oligopeptides of less than 10 kD and it has an absolute requirement for the trans-configuration of the peptide bond preceding proline. It cleaves peptide bonds at the C-terminal side of proline residues.

    参考文献
  • Oliveira EB, et al. (1976) Isolation of brain endopeptidases: Influence of size and sequence of substrates structurally related to bradykinin. Biochemistry. 15(9):1967-74.
  • Stepniak D, et al. (2006) Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease. Am J Physiol Gastrointest Liver Physiol. 291(4): G621-9.
  • Jarho EM, et al. (2007) 2(S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors. Bioorg Med Chem. 15(5):2024-31.
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    カタログ: MG50288-UT
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