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マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid

データシートレビュー関連製品プロトコル
Mouse LTA4H cDNA クローン製品情報
Gene_bank_ref_id:NM_008517.2
cDNA サイズ:1836bp
cDNA の説明:Full length Clone DNA of Mus musculus leukotriene A4 hydrolase.
遺伝子の別名:Lta4h
:Mouse
ベクター:pCMV3-untagged
Plasmid:
制限サイト:
タグ シーケンス:
シーケンスの説明:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
保存:The lyophilized plasmid can be stored at room temperature for three months.
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid on other vectors
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid, C-GFPSpark タグMG50268-ACGJPY59241
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid, C-OFPSpark タグMG50268-ACRJPY59241
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid, N-GFPSpark タグMG50268-ANGJPY59241
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid, N-OFPSpark タグMG50268-ANRJPY59241
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid, C-Flag タグMG50268-CFJPY51987
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid, C-His タグMG50268-CHJPY51987
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid, C-Myc タグMG50268-CMJPY51987
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid, C-HA タグMG50268-CYJPY51987
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone in cloning vectorMG50268-MJPY18135
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid, N-Flag タグMG50268-NFJPY51987
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid, N-His タグMG50268-NHJPY51987
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid, N-Myc タグMG50268-NMJPY51987
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmid, N-HA タグMG50268-NYJPY51987
マウス Leukotriene A4 Hydrolase/LTA4H Gene ORF cDNA clone expression plasmidMG50268-UTJPY51987
 発現ベクターの詳細情報
Product nameProduct name
背景

Mouse leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H and LTA4, is cytoplasm protein which belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity. The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may in turn be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses. As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is regarded as a therapeutic target for inflammation.

参考文献
  • Mancini, JA. et al.,1995, Eur. J. Biochem. 231: 65-71.
  • Orning, L. et al., 1994, J. Biol. Chem. 269: 11269-73.
  • Rudberg, PC. et al., 2004, J. Biol. Chem. 279: 27376-82.
  • Qiu, H. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 8161-6.
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    カタログ: MG50268-UT
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