BMP4 Protein, Mouse, Recombinant (Fc Tag)

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BMP4 Protein, Mouse, Recombinant (Fc Tag): 製品情報

純度
> 95 % as determined by SDS-PAGE.
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
活性
Testing in progress
タンパク質の構築
A DNA sequence encoding the mouse BMP4 (NP_031580.2) (Ser293-Arg408) was expressed with the Fc region of rabbit IgG at the N-terminus..
NP No.
発現ホスト
HEK293 Cells
Mouse
予測N末端
Ser
分子量
The recombinant mouse BMP4 consists 365 amino acids and predicts a molecular mass of 40.6 kDa.
バッファー
Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

BMP4 Protein, Mouse, Recombinant (Fc Tag): 画像

BMP4 Protein, Mouse, Recombinant (Fc Tag): 別名

Bmp-4 Protein, Mouse; Bmp2b Protein, Mouse; Bmp2b-1 Protein, Mouse; Bmp2b1 Protein, Mouse

BMP4 背景情報

BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling.
完全な名称
bone morphogenetic protein 4
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