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マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, N-His タグ

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    マウス ALOX5AP cDNA クローン製品情報
    Gene_bank_ref_id:NM_009663.1
    cDNA サイズ:486bp
    cDNA の説明:Full length Clone DNA of Mus musculus arachidonate 5-lipoxygenase activating protein with N terminal His tag.
    遺伝子の別名:Flap
    :Mouse
    ベクター:pCMV3-N-His
    Plasmid:
    制限サイト:
    タグ シーケンス:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
    シーケンスの説明:
    Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
    Promoter:Enhanced CMV mammalian cell promoter
    Application:Stable or Transient mammalian expression
    Antibiotic in E.coli:Kanamycin
    Antibiotic in mammalian cell:Hygromycin
    Shipping_carrier:Each tube contains lyophilized plasmid.
    保存:The lyophilized plasmid can be stored at room temperature for three months.
    His Tag Info

    A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

    Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.

    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, N-His タグ on other vectors
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, C-GFPSpark タグMG52815-ACGJPY54410
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, C-OFPSpark タグMG52815-ACRJPY54410
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, N-GFPSpark タグMG52815-ANGJPY54410
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, N-OFPSpark タグMG52815-ANRJPY54410
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, C-Flag タグMG52815-CFJPY47150
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, C-His タグMG52815-CHJPY47150
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, C-Myc タグMG52815-CMJPY47150
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, C-HA タグMG52815-CYJPY47150
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone in cloning vectorMG52815-GJPY18140
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, N-Flag タグMG52815-NFJPY47150
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, N-His タグMG52815-NHJPY47150
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, N-Myc タグMG52815-NMJPY47150
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmid, N-HA タグMG52815-NYJPY47150
    マウス ALOX5AP / 5-lipoxygenase-activating 蛋白質 Gene ORF cDNA clone expression plasmidMG52815-UTJPY47150
     発現ベクターの詳細情報
    Product nameProduct name
    背景

    Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP), also known as FLAP, belongs to the MAPEG family. ALOX5AP/FLAP is an essential partner of 5-LO for this process. The FLAP (ALOX5AP) gene has been linked to risk for myocardial infarction, stroke and restenosis, reigniting pharmaceutical interest in this target. It had been found that ALOX5AP/FLAP is a key enzyme in leukotriene formation, in both human pulmonary microvascular endothelial cells and a transformed human brain endothelial cell line. In addition, the protein FLAP has recently been identified as an emerging target in metabolic disease. In fact, FLAP is overexpressed in the adipose tissue of patients and experimental animals with obesity.

    参考文献
  • Gonsalves CS, et al. (2010) Hypoxia-mediated expression of 5-lipoxygenase-activating protein involves HIF-1alpha and NF-kappaB and microRNAs 135a and 199a-5p. J Immunol. 184(7): 3878-88.
  • Zintzaras E, et al. (2009) Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis. Am J Epidemiol. 169(5): 523-32.
  • Evans JF, et al. (2008) What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases. Trends Pharmacol Sci. 29(2): 72-8.
  • Bck M, et al. (2007) 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation. Circ Res. 100: 946-9.
  • Size / Price
    カタログ: MG52815-NH
    定価: 
    価格:      (You Save: )

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