AKR1A1 cDNA ORF Clone in Cloning Vector, Mouse

Cat: MG52953-G
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AKR1A1 cDNA ORF Clone in Cloning Vector, Mouse General Information
Gene
Species
Mouse
NCBI Ref Seq
RefSeq ORF Size
978 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence except for the point mutation: 636C>T not causing the amino acid variation.
Description
Full length Clone DNA of Mouse aldo-keto reductase family 1, member A1 (aldehyde reductase).
Plasmid
Vector
PGEM-T Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
AKR1A1 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

AKR1A1 cDNA ORF Clone in Cloning Vector, Mouse Alternative Names
2610201A18Rik cDNA ORF Clone, Mouse;Akr1a4 cDNA ORF Clone, Mouse
AKR1A1 Background Information

Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase. Aldehyde reductase has wide substrate specificities for carbonyl compounds. These enzymes are implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Aldehyde reductase possess a structure with a beta-alpha-beta fold which contains a novel NADP-binding motif. The binding site is located in a large, deep, elliptical pocket in the C-terminal end of the beta sheet, the substrate being bound in an extended conformation. This binding is more similar to FAD- than to NAD(P)-binding oxidoreductases. AKR1A1 is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue.

Full Name
aldo-keto reductase family 1, member A1 (aldehyde reductase)
References
  • Bohren KM, et al. (1989) The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases. J Biol Chem. 264 (16): 9547-51.
  • Fujii J, et al. (1999) The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome. Cytogenetics and Cell Genetics . 84 (3-4): 33-2.
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    AKR1A1 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    AKR1A1 cDNA ORF Clone, Mouse, untagged MG52953-UT
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    AKR1A1 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG52953-ACG
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    AKR1A1 cDNA ORF Clone, Mouse, C-Myc tag MG52953-CM
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    AKR1A1 cDNA ORF Clone, Human, Related Products

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