MSI2 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All MSI2 reagents are produced in house and quality controlled, including 1 MSI2 Antibody, 30 MSI2 Gene, 2 MSI2 qPCR. All MSI2 reagents are ready to use.

MSI2 の背景知識

The Musashi-2 (MSI2) protein, a regulator of mRNA translation, was consistently elevated in metastasis-competent cell lines.Musashi 2 (MSI2) is reported to be a potential oncoprotein in cases of leukemia and several solid tumors.The MSI2 RNA-binding protein has been demonstrated to have a role in acute myeloid leukaemia and stem cell function.The MSI2 RNA-binding protein is a potent oncogene playing key roles in haematopoietic stem cell homeostasis and malignant haematopoiesis. MSI2 is expressed in the intestinal stem cell compartment, that its expression is elevated in colorectal adenocarcinomas, and that MSI2 loss-of-function abrogates colorectal cancer cell growth.MSI2 is highly expressed in human myeloid leukemia (AML) cell lines, and high expression of MSI2 mRNA is associated with decreased survival in AML, suggesting its use as a new prognostic marker. MSI2 as a gene of Saccharomyces cerevisiae which, when on a multicopy vector, suppresses the heat shock sensitivity caused by the loss of the IRA1 product, a negative regulator of the RAS protein.