All MOG reagents are produced in house and quality controlled, including 7 MOG Antibody, 27 MOG Gene, 2 MOG Protein, 2 MOG qPCR. All MOG reagents are ready to use.
Recombinant MOG proteins are expressed by E. coli with fusion tags as C-His.
MOGantibodies are validated with different applications, which are ELISA, IHC-P, WB.
MOGcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each MOG of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals.