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Myelin oligodendrocyte glycoprotein  Protein, Antibody, ELISA Kit, cDNA Clone

Myelin oligodendrocyte glycoprotein 関連経路

Myelin oligodendrocyte glycoprotein サマリー & タンパク質情報

Myelin oligodendrocyte glycoprotein 背景

遺伝子の概要: The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
General information above from NCBI
サブユニット構造: Homodimer (By similarity). May form heterodimers between the different isoforms.
細胞内位置: Isoform 1: Cell membrane; Multi-pass membrane protein (Potential).
Isoform 5: Cell membrane; Multi-pass membrane protein (Potential).
Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential).
Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential).
Isoform 4: Cell membrane; Single-pass type I membrane protein (Potential).
Isoform 6: Cell membrane; Single-pass type I membrane protein (Potential).
Isoform 7: Cell membrane; Single-pass type I membrane protein (Potential).
Isoform 8: Cell membrane; Single-pass type I membrane protein (Potential).
Isoform 9: Cell membrane; Single-pass type I membrane protein (Potential).
組織特異性: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
疾患関連性: Narcolepsy 7 (NRCLP7) [MIM:614250]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye- movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Note=The disease is caused by mutations affecting the gene represented in this entry.
シーケンスの類似性: Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
General information above from UniProt

Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals.

Myelin oligodendrocyte glycoprotein 代替名

BTN6,BTNL11,MOGIG2,NRCLP7, [homo-sapiens]
DAQB-92E24.2,MGC26137,MOG,MOGIG2, [human]
B230317G11Rik,Mog, [mouse]
B230317G11Rik, [mus-musculus]

Myelin oligodendrocyte glycoprotein 関連研究

  • Chekhonin VP, et al. (2003) Myelin oligodendrogliocyte glycoprotein: the structure, functions, role in pathogenesis of demyelinating disorders. Biomed Khim. 49(5): 411-23.
  • Hilton AA, et al. (1995) Characterization of cDNA and Genomic Clones Encoding Human Myelin Oligodendrocyte Glycoprotein. J Neurochem. 65(1): 309-18.
  • Johns TG, et al. (1999) The Structure and Function of Myelin Oligodendrocyte Glycoprotein. J Neurochem. 72(1): 1-9.
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