MMP-3 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All MMP-3 reagents are produced in house and quality controlled, including 5 MMP-3 Antibody, 1 MMP-3 ELISA, 13 MMP-3 Gene, 1 MMP-3 Protein, 1 MMP-3 qPCR. All MMP-3 reagents are ready to use.

MMP-3 Protein (1)

MMP-3 Antibody (5)

MMP-3 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

MMP-3 cDNA Clone (13)

NM_002422.3

クローニングベクター cDNA 製品

In lentiviral vector

MMP-3 qPCR Primer (1)

MMP-3 の背景知識

Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in extracellular matrix. This protein is activated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP3 plays a central role in degrading collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP3 can also active other MMPs such as MMP1, MMP7, and MMP9, rendering MMP3 crucial in connective tissue remodeling. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

MMP-3 の参考文献

  • Sternlicht MD, et al. 1999, The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell. 98(2): 137-46.
  • Yoon S, et al. (1999) Genetic analysis of MMP3, MMP9, and PAI-1 in Finnish patients with abdominal aortic or intracranial aneurysms. Biochem Biophys Res Commun. 265(2): 563-8.
  • Biondi ML, et al. (2000) MMP1 and MMP3 polymorphisms in promoter regions and cancer. Clin Chem. 46(12): 2023-4.