All MMP-3 reagents are produced in house and quality controlled, including 4 MMP-3 Antibody, 1 MMP-3 ELISA, 13 MMP-3 Gene, 1 MMP-3 Protein, 1 MMP-3 qPCR. All MMP-3 reagents are ready to use.
Recombinant MMP-3 proteins are expressed by E. coli with fusion tags as Native.
MMP-3antibodies are validated with different applications, which are ELISA, ELISA(Cap), ELISA(Det).
MMP-3cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each MMP-3 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
MMP-3ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in extracellular matrix. This protein is activated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP3 plays a central role in degrading collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP3 can also active other MMPs such as MMP1, MMP7, and MMP9, rendering MMP3 crucial in connective tissue remodeling. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.