クイック注文

MBL/MBL-2  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: CHO Stable Cells  
10405-HNAS-50
10405-HNAS-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
50063-M04H-50
50063-M04H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
50063-M07H-50
50063-M07H-200
50 µg 
200 µg 
Add to Cart
  • Slide 1

MBL/MBL-2 Related Area

MBL/MBL-2 関連経路

MBL/MBL-2 サマリー & タンパク質情報

MBL/MBL-2 背景

遺伝子の概要: Human MBL2 gene is located on chromosome 10q11.2-q21. Mice have two homologous genes, but in human the first of them was lost. A low level expression of an MBL1 pseudogene 1 (MBL1P1) was detected in liver. The pseudogene encodes a truncated 51-amino acid protein that is homologous to the MBLA isoform in rodents and some primates
General information above from NCBI
サブユニット構造: Oligomeric complex of 3 or more homotrimers. Interacts with MASP1 and MASP2. Interacts with MEP1A and MEP1B and may inhibit their catalytic activity. {ECO:0000269|PubMed:16116208, ECO:0000269|PubMed:7634089, ECO:0000269|PubMed:9087411}.
ドメイン: The coiled-coil domain mediates trimerization.
細胞内位置: Secreted {ECO:0000269|PubMed:7982896}.
組織特異性: Plasma protein produced mainly in the liver. {ECO:0000269|PubMed:18006063}.
シーケンスの類似性: Contains 1 C-type lectin domain. {ECO:0000255|PROSITE-ProRule:PRU00040}.; Contains 1 collagen-like domain. {ECO:0000305}.
General information above from UniProt

MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcome for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.

MBL/MBL-2 代替名

MBL/MBL-2 関連研究

  • Garred P, et al. (2006) Mannose-binding lectin and its genetic variants. Genes Immun. 7(2): 85-94.
  • Brown KS, et al. (2007) Mannan binding lectin and viral hepatitis. Immunol Lett. 108(1): 34-44.
  • Garred P. (2008) Mannose-binding lectin genetics: from A to Z. Biochem Soc Trans. 36(Pt 6): 1461-6.
  • Garred P, et al. (2009) MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol. 46(14): 2737-44.
  • Muller YL, et al. (2010) Functional Variants in MBL2 Are Associated With Type 2 Diabetes and Pre-Diabetes Traits in Pima Indians and the Old Order Amish. Diabetes. 59(8): 2080-5.
  • 注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"