All M-CSF reagents are produced in house and quality controlled, including 12 M-CSF Antibody, 3 M-CSF ELISA, 26 M-CSF Gene, 8 M-CSF Lysate, 10 M-CSF Protein, 1 M-CSF qPCR. All M-CSF reagents are ready to use.
Recombinant M-CSF proteins are expressed by HEK293 Cells, Yeast with fusion tags as C-human IgG1-Fc, C-His, Native.
M-CSFantibodies are validated with different applications, which are ELISA, FCM, ELISA(Cap), ELISA(Det).
M-CSFcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each M-CSF of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
M-CSFELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.