SLAMF6 Protein, Human, Recombinant (His Tag)

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SLAMF6 Protein, Human, Recombinant (His Tag): 製品情報

純度
> 90 % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
活性
Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA.
タンパク質の構築
A DNA sequence encoding the human SLAMF6 (Q96DU3-1) extracellular domain (Met 1-Met 226) was expressed, with a polyhistidine tag at the C-terminus.
NCBI Reference No.
発現ホスト
HEK293 Cells
Human
予測N末端
Gln 22
分子量
The recombinant human SLAMF6 consists of 216 amino acids and predictes a molecular mass of 24.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhSLAMF6 is approximately 38-40 kDa due to glycosylation.
バッファー
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SLAMF6 Protein, Human, Recombinant (His Tag): 画像

SLAMF6 Protein, Human, Recombinant (His Tag): 別名

CD352 Protein, Human; KALI Protein, Human; KALIb Protein, Human; Ly108 Protein, Human; NTB-A Protein, Human; NTBA Protein, Human; SF2000 Protein, Human

SLAMF6 背景情報

SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly18, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly18 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly18 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly18 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly18 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly18 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.
完全な名称
SLAM family member 6
参考文献
  • Gray CW. et al., 2000, Eur J Biochem. 267 (18): 5699-710.
  • Bottino C. et al., 2001, J Exp Med. 194 (3): 235-46.
  • Valdez PA. et al., 2004, J Biol Chem. 279 (18): 18662-9.
  • Claus M. et al., 2007, Front Biosci. 13: 956-65.
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