LONP1: LONP1 Protein | LONP1 Antibody

LONP1 Gene family

LONP1 Protein

LONP1 protein function

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575).

LONP1 protein expression

Tissue specificity

Duodenum, heart, lung and liver, but not thymus.

LONP1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

LONP1 Antibody

There are 2 LONP1 antibodies which are validated in multiple tissues with various applications, including ELISA, IHC-P. There are 2 LONP1 antibody for ELISA, 1 LONP1 antibody for IHC-P. Among all these LONP1 antibodies, there are 2 anti-LONP1 rabbit polyclonal antibodies . All the LONP1 anbodies are produced in house and all are in stock. LONP1 antibody customerized service is available.

LONP1 Gene

LONP1 cDNA / gene is a gene with protein product which located on 19p13.2. The LONP1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog. 234 organisms have orthologs with human gene LONP1.