LDLR / LDL Receptor (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All LDLR / LDL Receptor reagents are produced in house and quality controlled, including 20 LDLR / LDL Receptor Antibody, 2 LDLR / LDL Receptor ELISA, 26 LDLR / LDL Receptor Gene, 3 LDLR / LDL Receptor Lysate, 5 LDLR / LDL Receptor Protein, 2 LDLR / LDL Receptor qPCR. All LDLR / LDL Receptor reagents are ready to use.

LDLR / LDL Receptor Protein (5)

LDLR / LDL Receptor Antibody (20)

LDLR / LDL Receptor ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

LDLR / LDL Receptor cDNA Clone (26)

NM_000527.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_010700.2

クローニングベクター cDNA 製品

In lentiviral vector

LDLR / LDL Receptor Lysate (3)

LDLR / LDL Receptor の背景知識

LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 84 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B1 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.

LDLR / LDL Receptor の参考文献

  • Yamamoto T, et al. (1984) The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 39(1): 27-38.
  • Mao B, et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 411(6835): 321-5.
  • Pinson KI, et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407(6803): 535-8.