Anti-Lipocalin-2 / LCN2 Antibody

1/1
Price:
Size:
Number:

Anti-Lipocalin-2 / LCN2 Antibody (Rabbit Polyclonal 抗体) の製品情報

製品名
Anti-Lipocalin-2 / LCN2 Antibody
検証済のアプリケーション
ELISA,IHC-P
交差反応
Reacts with: Human
特異性
Human Lipocalin-2 / LCN2
免疫原
Recombinant Human LCN2 protein (Catalog#10222-H08H)
調製
Produced in rabbits immunized with purified, recombinant Human Lipocalin-2 (rh Lipocalin-2; Catalog#10222-H08H; NP_005555.2; Met 1-Gly 198). LCN2 specific IgG was purified by human LCN2 affinity chromatography.
ソース
Polyclonal Rabbit IgG
精製
Protein A & Antigen Affinity
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Lipocalin-2 / LCN2 Antibody (Rabbit Polyclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:1000-1:2000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Lipocalin-2 / LCN2 Antibody (Rabbit Polyclonal 抗体) の画像

Immunochemical staining of human LCN2 in human spleen with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-Lipocalin-2 / LCN2 Antibody: 別名

Anti-24p3 Antibody; Anti-Lipocalin-2 Antibody; Anti-MSFI Antibody; Anti-NGAL Antibody; Anti-p25 Antibody

Lipocalin-2 / LCN2 背景情報

Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.
氏名
lipocalin 2
参考文献
  • Schmidt-Ott KM, et al. (2006) Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia. Curr Opin Nephrol Hypertens. 15(4): 442-9.
  • Bolignano D, et al. (2010) Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene. Cancer Lett. 288(1): 10-6.
  • Soni SS, et al. (2010) NGAL: a biomarker of acute kidney injury and other systemic conditions. Int Urol Nephrol. 42(1): 141-50.
  • Bolignano D, et al. (2010) From kidney to cardiovascular diseases: NGAL as a biomarker beyond the confines of nephrology. Eur J Clin Invest. 40(3): 273-6.
カートに追加しました カートに追加しませんでした カートを更新しています。少々お待ちください