LAG3 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All LAG3 reagents are produced in house and quality controlled, including 1 LAG3 Antibody, 43 LAG3 Gene, 11 LAG3 Lysate, 11 LAG3 Protein, 1 LAG3 qPCR. All LAG3 reagents are ready to use.

LAG3 Protein (11)

LAG3 Antibody (1)

LAG3 cDNA Clone (43)

NM_002286.5

クローニングベクター cDNA 製品

In lentiviral vector

NM_008479.2

クローニングベクター cDNA 製品

In expression vector

In lentiviral vector

NM_212513.2

クローニングベクター cDNA 製品

In lentiviral vector

XM_001108923.2

クローニングベクター cDNA 製品

In lentiviral vector

LAG3 qPCR Primer (1)

LAG3 Lysate (11)

LAG3 の背景知識

LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.

LAG3 の参考文献

  • Sigrid Hannier. et al., 1998, The Journal of Immunology. 161(8): 4058-65.
  • Triebel F. et al., 1990, J Exp Med. 171 (5): 1393-405.
  • Baixeras E. et al., 1992, J Exp Med. 176 (2): 327-37.
  • Huard B. et al., 1997, Proc Natl Acad Sci. 94 (11): 5744-9.
  • Kisielow M. et al., 2005, Eur J Immunol. 35 (7): 2081-8.