All LAG3 reagents are produced in house and quality controlled, including 1 LAG3 Antibody, 43 LAG3 Gene, 11 LAG3 Lysate, 11 LAG3 Protein, 1 LAG3 qPCR. All LAG3 reagents are ready to use.
Recombinant LAG3 proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc, C-mouse IgG1-Fc, Native.
LAG3antibodies are validated with different applications, which are ELISA.
LAG3cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each LAG3 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.