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LAG3/LAG-3/CD223  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
  • Slide 1
16498-H08H-50
16498-H08H-200
50 µg 
200 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
16498-H05H-50
16498-H05H-200
50 µg 
200 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
16498-H02H-50
16498-H02H-200
50 µg 
200 µg 
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発現宿主: Human Cells  
  • Slide 1
  • Slide 1
53069-M08H3-50
53069-M08H3-200
50 µg 
200 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
53069-M08H-50
53069-M08H-200
50 µg 
200 µg 
Add to Cart
発現宿主: Human Cells  
  • Slide 1
53069-M02H-50
53069-M02H-200
50 µg 
200 µg 
Add to Cart
製品の説明:   
発現宿主: Human Cells  
  • Slide 1
80367-R08H-50
80367-R08H-100
50 µg 
100 µg 
Add to Cart

LAG3/LAG-3/CD223 Related Area

LAG3/LAG-3/CD223 関連経路

    LAG3/LAG-3/CD223 サマリー & タンパク質情報

    LAG3/LAG-3/CD223 背景

    細胞内位置: Membrane; Single-pass type I membrane protein.
    組織特異性: On cell surface of activated NK and T-lymphocytes.
    シーケンスの類似性: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.

    Immune Checkpoint
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    LAG3/LAG-3/CD223 代替名

    LAG-3, []
    CD223, [homo-sapiens]
    lymphocyte-activation gene 3,LAG3,CD223,lymphocyte activation gene 3 protein, [human]
    lymphocyte-activation gene 3,Lag3,CD223,LAG-3,Ly66,lymphocyte activation gene 3 protein, [mouse]
    Ly66,CD223,LAG-3, [mus-musculus]

    LAG3/LAG-3/CD223 関連研究

  • Sigrid Hannier. et al., 1998, The Journal of Immunology. 161(8): 4058-65.
  • Triebel F. et al., 1990, J Exp Med. 171 (5): 1393-405.
  • Baixeras E. et al., 1992, J Exp Med. 176 (2): 327-37.
  • Huard B. et al., 1997, Proc Natl Acad Sci. 94 (11): 5744-9.
  • Kisielow M. et al., 2005, Eur J Immunol. 35 (7): 2081-8.
  • 注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"