Influenza A Virus Hemagglutinin / HA Antibody, Rabbit MAb

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Influenza A Virus Hemagglutinin / HA Antibody, Rabbit MAb (Rabbit Monoclonal 抗体) の製品情報

製品名
Influenza A Virus Hemagglutinin / HA Antibody, Rabbit MAb
検証済のアプリケーション
WB,ELISA,IHC-P,FCM,ICC/IF,IF,IP (Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.)
アプリケーションの説明
(Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.)
特異性
Influenza Hemagglutinin / HA
Has cross-reactivity in ELISA with
H1N1 (A/Brisbane/59/2007) HA
H1N1 (A/Solomon Islands/3/2006) HA
H1N1 (A/Ohio/UR06-0091/2007) HA
H1N1 (A/New Caledonia/20/1999) HA
H1N1 (A/Puerto Rico/8/1934) HA
H1N1 (A/WSN/1933) HA
H1N2 (A/swine/Guangxi/13/2006) HA
H1N3 (A/duck/NZL/160/1976) HA
H5N1 (A/Anhui/1/2005) HA
H5N1 (A/Anhui/1/2005) HA2 Sub-unit
H5N1 (A/turkey/Turkey/1/2005) HA
H5N1 (A/Indonesia/5/2005) HA
H5N1 (A/bar-headed goose/Qinghai/14/2008) HA
H5N1 (A/Viet Nam/1203/2004) HA
No cross-reactivity in ELISA with
H1N1 (A/BrevigMission/1/1918) HA
H1N1 (A/California/04/2009) HA1 Sub-unit
H3N2 (A/Brisbane/10/2007) HA
Influenza B (B/Florida/4/2006) HA
免疫原
Recombinant H1N1 HA protein
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Influenza A virus H1N1 Hemagglutinin extracellular domain.
ソース
Monoclonal Rabbit IgG Clone #133
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Influenza A Virus Hemagglutinin / HA Antibody, Rabbit MAb (Rabbit Monoclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
WB his antibody can be used at 1:500-1:1000 with the appropriate secondary reagents to detect H1N1 HA in WB.
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Hemagglutinin / HA 背景情報

The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane.The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
完全な名称
Harvey rat sarcoma viral oncogene homolog
参考文献
  • White JM, Hoffman LR, Arevalo JH, et al. (1997). ""Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin"". In Chiu W, Burnett RM, Garcea RL. Structural Biology of Viruses.
  • Suzuki Y (March 2005). ""Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses"". Biol. Pharm. Bull. 28 (3): 399–408.
  • Senne DA, Panigrahy B, Kawaoka Y, et al. (1996). ""Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential"". Avian Dis. 40 (2): 425–37
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