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H6N1 (Influenza A) Protein, Antibody, Gene cDNA Clone & ELISA Kit

H6N1 (Influenza A ) Background

H6N1 is a subtype of the species Influenza A virus. An H6N1 virus isolated from teal, called A/teal/Hong Kong/W312/97 (H6N1), showed very high (>98%) nucleotide homology to the human influenza virus A/Hong Kong/156/97 (H5N1) in the six internal genes. The N1 neuraminidase sequence showed 97% nucleotide homology to that of the human H5N1 virus, and the N1 protein of both viruses had the same 19-amino-acid deletion in the stalk region. The deduced hemagglutinin amino acid sequence of the H6N1 virus was most similar to that of A/shearwater/Australia/1/72 (H6N5). The H6N1 virus is the first known isolate with seven H5N1-like segments and may have been the donor of the neuraminidase and the internal genes of the H5N1 viruses. The high homology between the internal genes of H9N2, H6N1, and the H5N1 isolates indicates that these subtypes are able to exchange their internal genes and are therefore a potential source of new pathogenic influenza virus strains. It was indicated that H6N1 might be a derivative or a precursor of H5N1.

Influenza (flu) is a respiratory infection in mammals and birds. It is caused by an RNA virus in the family Orthomyxoviridae. The virus is divided into three main types (Influenza A, Influenza B, and Influenza C), which are distinguished by differences in two major internal proteins (hemagglutinin (HA) and neuraminidase (NA)). Influenza virus type A is found in a wide variety of bird and mammal species and can undergo major shifts in immunological properties. Influenza B is largely confined to humans and is an important cause of morbidity. Little is known about Influenza C, which is not an important source of morbidity.

Influenza A is further divided into subtypes based on differences in the membrane proteins hemagglutinin (HA) and neuraminidase (NA), which are the most important targets for the immune system. The notation HhNn is used to refer to the subtype comprising the hth discovered Hemagglutinin (HA) protein and the nth discovered neuraminidase (NA) protein. The influenza viral hemagglutinin (HA) is a single-pass type I integral membrane glycoprotein. It is a homo trimer containing a central α helix coil and three spherical heads with the sialic acid binding sites. The influenza virus neuraminidase (NA) protein is a second major surface antigen of the virion. Neuraminidase cleaves terminal sialic acid from glycoproteins or glycolipids, and promotes influenza virus release from infected cells and facilitates virus spread within the respiratory tract.