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CD18/Integrin beta 2/ITGB2  Protein, Antibody, ELISA Kit, cDNA Clone

CD18/Integrin beta 2/ITGB2 Related Area

CD18/Integrin beta 2/ITGB2 関連経路

CD18/Integrin beta 2/ITGB2 サマリー & タンパク質情報

CD18/Integrin beta 2/ITGB2 背景

サブユニット構造: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with FGR (By similarity). Interacts with COPS5 and RANBP9. {ECO:0000250, ECO:0000269|PubMed:10766246, ECO:0000269|PubMed:14722085, ECO:0000269|PubMed:20033057}.
細胞内位置: Membrane; Single-pass type I membrane protein.
翻訳後: Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins. {ECO:0000269|PubMed:11700305}.
疾患関連性: DISEASE: Leukocyte adhesion deficiency 1 (LAD1) [MIM:116920]: LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions. {ECO:0000269|PubMed:1346613, ECO:0000269|PubMed:1347532, ECO:0000269|PubMed:1352501, ECO:0000269|PubMed:1590804, ECO:0000269|PubMed:1694220, ECO:0000269|PubMed:1968911, ECO:0000269|PubMed:20529581, ECO:0000269|PubMed:20549317, ECO:0000269|PubMed:7509236, ECO:0000269|PubMed:7686755, ECO:0000269|PubMed:9884339}. Note=The disease is caused by mutations affecting the gene represented in this entry.
シーケンスの類似性: Belongs to the integrin beta chain family. {ECO:0000305}.; Contains 1 VWFA domain. {ECO:0000305}.
General information above from UniProt

Integrins form a family of heterodimeric transmembrane receptors that regulate cell–adhesion and cell-extracellular matrix interactions. Lymphocyte function-associated antigen 1 (LFA-1, αLβ2) is a leukocyte specific integrin that mediates firm arrest of leukocytes on the endothelium during migration and establishes cell-cell contacts such as the immunological synapse between DCs and T cells. At the molecular level, transient modifications of adhesion are accomplished by conformational changes of LFA-1 from a bent down inactive to an upright active conformation with an open headpiece, leading to low- and high-affinity for its major ligand ICAM-1 respectively.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

CD18/Integrin beta 2/ITGB2 代替名

LFA-1,MAC-1,CD18,MF17,MFI7,LCAMB,LAD, [homo-sapiens]
2000000,LAD,Cd18,Lfa1,MF17,LCAMB,AI528527, [mus-musculus]

CD18/Integrin beta 2/ITGB2 関連研究

  • Eich C, Lasonder E, Cruz LJ, et al. Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells. Mattei F, ed. PLoS ONE. 2016;11(2):e0149637.
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