Anti-IL-6 Antibody

Cat: 90197-RP02
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All IL-6 Reagents
Anti-IL-6 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL-6 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Rhesus
Specificity
Rhesus IL-6
Immunogen
Recombinant Rhesus IL6 / Interleukin-6 protein (Catalog#90197-CNAE)
Preparation
Produced in rabbits immunized with purified, recombinant Rhesus IL6 / Interleukin-6 (Catalog#90197-CNAE; NP_001036198.2; Pro29-Met212). IL6 / Interleukin-6 specific IgG was purified by Rhesus IL6 / Interleukin-6 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IL-6 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:1000-1:4000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IL-6 Antibody (Rabbit Polyclonal antibody) Images
Cynomolgus IL6/IL-6/Interleukin-6 Immunohistochemistry(IHC) 4791
Immunochemical staining of Rhesus IL6 in human tonsil with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Cynomolgus IL6/IL-6/Interleukin-6 Immunohistochemistry(IHC) 4792
Immunochemical staining of Rhesus IL6 in human spleen with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
Cynomolgus IL6/IL-6/Interleukin-6 Immunohistochemistry(IHC) 4793
Immunochemical staining of Rhesus IL6 in human liver with rabbit polyclonal antibody (1:2000, formalin-fixed paraffin embedded sections).
IL-6 Background Information

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
interleukin 6
References
  • Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.
  • Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24.
  • Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IL-6 Antibody Rabbit Polyclonal ELISA 62006-T16
    Anti-IL-6 Antibody Rabbit Polyclonal ELISA 90197-RP01
    Anti-IL-6 Antibody Rabbit Polyclonal ELISA 62006-RP01
    Anti-IL-6 Antibody Rabbit Polyclonal ELISA 80076-T16
    Anti-IL-6 Antibody Rabbit Monoclonal ELISA 80076-R007
    Anti-IL-6 Antibody Rabbit Polyclonal ELISA 50136-T16
    Anti-IL-6 Antibody Rabbit Polyclonal ELISA 50136-RP01
    Anti-IL-6 Antibody Mouse Monoclonal ELISA 10395-MM02
    Anti-IL-6 Antibody Mouse Monoclonal ELISA(Det) 10395-MM72
    Anti-IL-6 Antibody Mouse Monoclonal Neutralization 10395-MK23
    Anti-IL-6 Antibody Rabbit Polyclonal WB,ELISA 10395-RP03
    Anti-IL-6 Antibody Rabbit Monoclonal ELISA 10395-R057
    Anti-IL-6 Antibody Rabbit Polyclonal WB,ELISA 10395-T48
    Anti-IL-6 Antibody Rabbit Polyclonal ELISA 10395-T16
    Anti-IL-6 Antibody Rabbit Polyclonal WB,ELISA,IP 10395-T52
    Anti-IL-6 Antibody Mouse Monoclonal Neutralization 10395-mhK23
    Anti-IL-6 Antibody Mouse Monoclonal IHC-P 10395-MM10
    Anti-IL-6 Antibody Rabbit Monoclonal Neutralization 10395-R508
    Anti-IL-6 Antibody Rabbit Polyclonal ELISA 10395-RP01
    Anti-IL-6 Antibody Mouse Monoclonal ELISA,ELISA(Cap) 10395-MM14
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