IL-5 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All IL-5 reagents are produced in house and quality controlled, including 11 IL-5 Antibody, 2 IL-5 ELISA, 65 IL-5 Gene, 3 IL-5 Lysate, 4 IL-5 Protein, 3 IL-5 qPCR. All IL-5 reagents are ready to use.

IL-5 Protein (4)

IL-5 Antibody (11)

IL-5 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

IL-5 cDNA Clone (65)

NM_000879.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_010558.1

クローニングベクター cDNA 製品

In lentiviral vector

NM_021834.1

クローニングベクター cDNA 製品

In lentiviral vector

NM_001006950.1

クローニングベクター cDNA 製品

In lentiviral vector

EHH26772.1

クローニングベクター cDNA 製品

In lentiviral vector

IL-5 Lysate (3)

IL-5 の背景知識

Interleukin 5 (IL-5) is a member of the interleukin family with length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins / signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered as a key mediator in eosinophil activation. Interleukin 5 (IL-5) has long been associated with several allergic diseases, including allergic rhinitis and asthma. Growth in the number of circulating, airway tissue, and induced sputum eosinophils have been observed in patients with these diseases. IL-5 also had something with the terminally differentiated granulocyte eosinophils. IL-5 was originally found as an eosinophil colony stimulating factor. It has been proved to be a major regulator of eosinophil accumulation in tissues, and can modulate eosinophil behavior at every stage from maturation to survival.

IL-5 の参考文献

  • Milburn MV, et al. (1993) A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5. Nature. 363(6425): 172-176.
  • Lee JS, et al. (1989) The IL-4 and IL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11. Somat Cell Mol Genet. 15(2): 143-152.
  • Woodcock JM, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13 (21): 5176-85.