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IL17A/IL-17A/IL17  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Yeast  
12047-H07Y-50
12047-H07Y-100
50 µg 
100 µg 
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  • Slide 1
発現宿主: E. coli  
12047-HNAE-5
12047-HNAE-20
12047-HNAE-100
5 µg 
20 µg 
100 µg 
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  • Slide 1
発現宿主: Baculovirus-Insect Cells  
12047-H07B-50
12047-H07B-5
12047-H07B-20
12047-H07B-100
50 µg 
5 µg 
20 µg 
100 µg 
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  • Slide 1
発現宿主: CHO Stable Cells  
12047-HNAS-500
12047-HNAS-5
12047-HNAS-20
12047-HNAS-100
12047-HNAS-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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  • Slide 1
製品の説明: Active  
発現宿主: E. coli  
51065-MNAE-50
51065-MNAE-20
50 µg 
20 µg 
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  • Slide 1
発現宿主: E. coli  
70102-DNAE-50
70102-DNAE-100
50 µg 
100 µg 
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  • Slide 1
発現宿主: Baculovirus-Insect Cells  
90306-KNAB-20
90306-KNAB-100
20 µg 
100 µg 
Add to Cart
  • Slide 1
製品の説明:   
発現宿主: Baculovirus-Insect Cells  
65006-T07B-5
65006-T07B-20
65006-T07B-100
5 µg 
20 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: E. coli  
90287-CNAE-50
90287-CNAE-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

IL17A/IL-17A/IL17 Related Area

IL17A/IL-17A/IL17 関連製品

IL17A/IL-17A/IL17 サマリー & タンパク質情報

IL17A/IL-17A/IL17 背景

遺伝子の概要: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis
General information above from NCBI
サブユニット構造: Homodimer. {ECO:0000269|PubMed:19835883}.
細胞内位置: Secreted.
組織特異性: Restricted to activated memory T-cells.
翻訳後: Found both in glycosylated and nonglycosylated forms.
シーケンスの類似性: Belongs to the IL-17 family. {ECO:0000305}.
General information above from UniProt

IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

IL17A/IL-17A/IL17 代替名

IL17,CTLA8,IL-17,IL-17A, [homo-sapiens]
CTLA8,CTLA-8,cytotoxic T-lymphocyte-associated antigen 8,cytotoxic T-lymphocyte-associated protein 8,cytotoxic T-lymphocyte-associated serine esterase 8,IL17,IL-17,IL-17A,interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8),interleukin-17A, [human]
Ctla8,Ctla-8,cytotoxic T-lymphocyte-associated antigen 8. interleukin-17A,Il17,IL-17,IL-17A, [mouse]
Il17,Ctla8,IL-17,Ctla-8,IL-17A, [mus-musculus]

IL17A/IL-17A/IL17 関連研究

  • Andoh A, et al. (2002) IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. J Immunol. 169(4):1683-7.
  • Kotake S, et al. (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 103(9):1345-52.
  • Laan M, et al. (1999) Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol. 162(4):2347-52.
  • Shin HC, et al. (1999) Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine. 10(11):841-50.
  • 注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"