All IL12B reagents are produced in house and quality controlled, including 16 IL12B Antibody, 1 IL12B ELISA, 91 IL12B Gene, 9 IL12B Lysate, 9 IL12B Protein, 3 IL12B qPCR. All IL12B reagents are ready to use.
Recombinant IL12B proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His, C-cleavage.
IL12Bantibodies are validated with different applications, which are ELISA, IHC-P, ELISA(Cap), ELISA(Det).
IL12BcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL12B of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
IL12BELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity.