IL4R (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All IL4R reagents are produced in house and quality controlled, including 15 IL4R Antibody, 1 IL4R ELISA, 17 IL4R Gene, 7 IL4R Lysate, 7 IL4R Protein, 2 IL4R qPCR. All IL4R reagents are ready to use.

IL4R Protein (7)

IL4R Antibody (15)

IL4R ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

IL4R cDNA Clone (17)

NM_000418.3

In expression vector

In lentiviral vector

NM_133380.2

クローニングベクター cDNA 製品

In lentiviral vector

CM001295.1

In expression vector

IL4R Lysate (7)

IL4R の背景知識

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD124, also known as interleukin 4 receptor (IL4R), is a typeⅠ transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.

IL4R の参考文献

  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.